|Bioscience Lab Services

As a core component of the mission of multiple federal agencies, the successful conduct of safe, secure and responsive research involving infectious pathogens requires an effective balance of intellectual freedom, program-driven objectives, and regulatory controls. Recent events, including the emergence of Middle East Respiratory Syndrome (MERS), underscore the need for programs and facilities dedicated to the understanding of emerging and established infectious diseases that pose a threat to public health.

Tunnell Government Services (TGS) understands the scientific and technical requirements needed for the research and development of medical countermeasures for high-consequence infectious diseases. We support these efforts by providing highly specialized scientific staff, including physicians, veterinarians, virologists, immunologists, biophysicists and histologists, enabling a broad spectrum of activities, as outlined below:

♦ Biocontainment research, including (animal) biosafety level 4 research

♦ Viral pathogenesis studies

♦ Animal model development (in close coordination with FDA requirements)

♦ Medical countermeasure discovery, evaluation, and development

♦ Biological threat characterization

♦ Medical imaging of virus infections

Since 2007, TGS has successfully performed as a subcontractor in support of the NIH/NIAID Integrated Research Facility at Fort Detrick (IRF-Frederick), providing scientific leadership and research support involving the study of mechanisms of virulence of arteriviruses, bunyaviruses, coronaviruses, filoviruses, arenaviruses and orthopoxviruses both in vitro and in animal models. Operating within this facility’s (animal) biosafety level 4 (BSL-4) containment suites, TGS personnel are actively engaged in fulfilling IRF-Frederick’s mission to evaluate and develop effective treatments and therapeutics for a wide variety of human Select Agents for future FDA licensure.

Reference Materials

Project Brief–Program Support–HHS
Project Brief–Program Support–NIH
Integrated Sustainable Solutions

Press

Jens Kuhn Presents Commentary on ``Bats and Human Health`` in Issues in Science and Technology
Jens Kuhn Presents Commentary on “Bats and Human Health” in Issues in Science and Technology

07/17/2017

 

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Jens Kuhn Co-Authors Article on Genome Sequence of a Novel Kunsagivirus (Picornaviridae: Kunsagivirus) from a Wild Baboon
Jens Kuhn Co-Authors Article on Genome Sequence of a Novel Kunsagivirus (Picornaviridae:  Kunsagivirus) from a Wild Baboon, published in “Genome Announcements”

05/9/2017

 

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Jens Kuhn Co-Authors Article on Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses
Jens Kuhn Co-Authors Article on Implementation of Objective PASC-Derived Taxon Demarcation Criteria for Official Classification of Filoviruses.  Published in “Viruses”

05/11/2017

 

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Jens Kuhn Co-Authors Article on ``Asymptomatic Ebola virus infections - myth or reality?``
Jens Kuhn Authors Article on Asymptomatic Ebola virus infections – myth or reality?

06/21/2017

 

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Jens Kuhn Co-Authors Article for ``Inhalation Toxicology``
Jens Kuhn Co-Authors Article For “Inhalation Toxicology”

01/11/2017

Tunnell Principal Jens Kuhn co-authors article on “Comparison of Respiratory Inductive Plethysmography Versus Head-Out Plethysmography for Nonhuman Primates in an Animal Biosafety Level 4 Facility”.

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Jens Kuhn Co-Authors Article on Ebola Virus Trailer
Jens Kuhn Co-Authors Article on Ebola Virus Trailer

01/11/2017

Jens Kuhn co-authors article on “A Small Stem-Loop Structure of the Ebola Virus Trailer is Essential for Replication and Interacts with Heat-Shock Protein A8”.

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Jens Kuhn Co-Authors Report on Infections Caused by Bornaviruses
Jens Kuhn Co-Authors Report on Infections Caused by Bornaviruses

01/11/2017

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Jens Kuhn Co-Authors Article on Ebola Virus Istolate
Jens Kuhn Co-Authors Article on Ebola Virus Istolate

01/11/2017

Jens Kuhn, Ph.D. has co-authored an article on “Sequence of Reston Virus Isolate AZ-1435, an Ebola Virus Isolate Obtained During the 1989-1990 Reston Virus Epizootic in the US.”

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Dr. Kuhn Co-Authors Chapter on Filoviruses
Dr. Kuhn Co-Authors Chapter on Filoviruses

02/01/2017

Jens Kuhn has co-authored a chapter on Filoviruses for an article on Mononegaviruses of Veterinary Importance for Vol. 2–Molecular Epidemiology & Control.

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Jens Kuhn, Ph.D, Co-Authors Article on Simian Arterivurses
Jens Kuhn, Ph.D, Co-Authors Article on Simian Arterivurses

02/01/2017

Dr. Jens Kuhn has co-authored an article on “Within-Host Evolution of Simian Arteriviruses in Crab Eating Macaques” for the Journal of Virology.

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Dr. Kuhn Co-Authors on RNA Virus Population
Dr. Kuhn Co-Authors on RNA Virus Population

02/17/2017

Jens Kuhn, Ph.D., has co-authored a publication on “Error Baseline Rates of Five Sample Preparation Methods Used to Characterize RNA Virus Populations”.

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